Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis - Cognitions Humaine et Artificielle Access content directly
Journal Articles Cell Reports Year : 2023

Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis

Thomas Darde
  • Function : Author
Ana Cumano
  • Function : Author

Abstract

Changes in lymphocyte production patterns occurring across human ontogeny remain poorly defined. In this study, we demonstrate that human lymphopoiesis is supported by three waves of embryonic, fetal, and postnatal multi-lymphoid progenitors (MLPs) differing in CD7 and CD10 expression and their output of CD127-/+ early lymphoid progenitors (ELPs). In addition, our results reveal that, like the fetal-to-adult switch in erythropoiesis, transition to postnatal life coincides with a shift from multilineage to B lineage-biased lymphopoiesis and an increase in production of CD127+ ELPs, which persists until puberty. A further developmental transition is observed in elderly individuals whereby B cell differentiation bypasses the CD127+ compartment and branches directly from CD10+ MLPs. Functional analyses indicate that these changes are determined at the level of hematopoietic stem cells. These findings provide insights for understanding identity and function of human MLPs and the establishment and maintenance of adaptative immunity.
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licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

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pasteur-04137202 , version 1 (22-06-2023)

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Attribution - NonCommercial - NoDerivatives

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Seydou Keita, Samuel Diop, Shalva Lekiashvili, Emna Chabaane, Elisabeth Nelson, et al.. Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis. Cell Reports, 2023, 42 (6), pp.112618. ⟨10.1016/j.celrep.2023.112618⟩. ⟨pasteur-04137202⟩
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