The architecture and chronology of Late Pleistocene to Holocene alluvial deposits in the lower Garonne have been studied in details based on data (boreholes, trenches, ground-penetrating radar profiles, numerical dating) collected in quarries and during archaeological surveys. The preserved alluvial bodies, dated between ca. 38 ka and present, show that the river retained a meandering or anabranching pattern throughout this period, associated with the formation of lateral accretion packages and scroll bars in the convexity of meanders. Valley incision in connection to the LGM low sea level reached up to 19 m in the study area, and occurred between ca. 26 and 18 ka. Since ca. 18 ka, the lateral migration of meanders widened the plain without any significant incision of the Oligocene marl bedrock. The Early-Middle Holocene was characterized by the development of highly sinuous meanders, while sinuosity decreased in a late phase including the Little Ice Age. Comparison with other lowland European rivers shows that the persistence of a meandering or anabranching pattern during MIS 2 is not an isolated case. The documented examples are associated with rivers typified by low valley slope, or situated in southern regions unaffected by permafrost and characterized by dense vegetation. The latter conditions would not have led to a drastic change in river discharge and bedload transport during the Last Glacial, as was the case for more northerly rivers where braiding seems to have been common.